霜霉病
杀菌剂
阿米西达
EC50型
哌嗪
化学
吡啶
生物
药物化学
园艺
有机化学
生物化学
体外
作者
Ying Xu,Hongtao Wang,Xiaohua Du
摘要
Cucumber downy mildew (CDM) is a severe plant disease and affects the yield of cucumber production worldwide. As the resistance toward conventional fungicides is emerging as a ubiquitous issue, it is urgent to discover efficient fungicides with unique structures.In this study, a series of novel phenylpyridine derivatives were designed and synthesized. Bioassays revealed that most of these compounds possessed excellent fungicidal activities against CDM. Among the phenylpyridine compounds, 2-(4-(4-(tert-butyl)benzyl)piperazin-1-yl)-6-phenylnicotinonitrile (C8) [half-maximal effective concentration (EC50 ) = 4.40 mg L-1 ] displayed the highest activity, which was better than those of the commercial fungicides, such as azoxystrobin (EC50 = 42.77 mg L-1 ) and flumorph (EC50 = 41.94 mg L-1 ). Furthermore, the molecular electrostatic potential of high-activity compound C8 indicated that nitrogen atom of the cyano group on the pyridine ring was in the negative region and may easily form hydrogen bonds and allow for electrostatic interactions with potential receptors.This study demonstrated that the novel N-substituted piperazine-containing phenylpyridine derivatives could be further developed as a candidate compound to control CDM.
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