α-2-巨球蛋白
蛋白酵素
阿尔法(金融)
蛋白酶
胰蛋白酶
蛋白酶抑制剂(药理学)
转化(遗传学)
化学
巨球蛋白
酶
生物
生物化学
免疫学
医学
病毒
护理部
结构效度
病毒载量
患者满意度
基因
抗逆转录病毒疗法
作者
Xiaoxing Huang,Youwang Wang,Cong Yu,Hui Zhang,Qiang Ru,Xinxin Li,Kai Song,Min Zhou,Ping Zhu
标识
DOI:10.1007/s11427-022-2139-2
摘要
Human alpha-2-macroglobulin is a well-known inhibitor of a broad spectrum of proteases and plays important roles in immunity, inflammation, and infections. Here, we report the cryo-EM structures of human alpha-2-macroglobulin in its native state, induced state transformed by its authentic substrate, human trypsin, and serial intermediate states between the native and fully induced states. These structures exhibit distinct conformations, which reveal the dynamic transformation of alpha-2-macro-globulin that acts as a protease inhibitor. The results shed light on the molecular mechanism of alpha-2-macroglobulin in entrapping substrates.
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