声动力疗法
材料科学
活性氧
单线态氧
异质结
体内
纳米技术
癌细胞
癌症
癌症研究
生物物理学
氧气
化学
光电子学
医学
生物化学
生物
内科学
生物技术
有机化学
作者
Yunchao Zhao,Shaobo Wang,Yiming Ding,Zeyu Zhang,Tian Huang,Yalong Zhang,Xingyi Wan,Zhong Lin Wang,Linlin Li
出处
期刊:ACS Nano
[American Chemical Society]
日期:2022-06-14
卷期号:16 (6): 9304-9316
被引量:90
标识
DOI:10.1021/acsnano.2c01968
摘要
Ultrasound (US)-triggered sonodynamic therapy (SDT) based on semiconductor nanomaterials has attracted considerable attention for cancer therapy. However, most inorganic sonosensitizers suffer from low efficiency due to the rapid recombination of electron–hole pairs. Herein, the Cu2–xO–BaTiO3 piezoelectric heterostructure was fabricated as a sonosensitizer and chemodynamic agent, simultaneously, for improving reactive oxygen species (ROS) generation and cancer therapeutic outcome. Under US irradiation, the Cu2–xO–BaTiO3 heterojunction with a piezotronic effect exhibits high-performance singlet oxygen (1O2) and hydroxyl radical (•OH) generation to enhance SDT. Moreover, it possesses Fenton-like reaction activity to convert endogenous H2O2 into •OH for chemodynamic therapy (CDT). The integration of SDT and CDT substantially boosts ROS generation and cellular mitochondria damage, and the in vitro and in vivo results demonstrate high cytotoxicity and tumor inhibition on murine refractory breast cancer. This work realizes improvement in cancer therapy using piezoelectric heterostructures with piezotronic effects.
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