B细胞激活因子
免疫学
自身抗体
发病机制
自身免疫性疾病
B细胞
自身免疫
生物
癌症研究
医学
免疫系统
抗体
作者
Yidan Zhang,Jie Tian,Fan Xiao,Leting Zheng,Xiaoxia Zhu,Ling Wu,Cheng Zhao,Shengjun Wang,Ke Rui,Hejian Zou,Liwei Lu
标识
DOI:10.1016/j.cytogfr.2021.11.004
摘要
B cells play a pivotal role in the pathogenesis of autoimmune disease (AD) by the production of autoantibodies, secretion of cytokines and presentation of autoantigens. As a pro-survival factor mainly produced by myeloid cells, B cell-activating factor (BAFF) maintains B cell maturation and homeostasis at various B cell differentiation stages. Under autoimmune conditions, BAFF acts on autoreactive B cells that have escaped checkpoint apoptosis from negative selection. Numerous studies have shown increased levels of BAFF in patients with ADs and in mouse models with ADs wherein the production of autoantibodies is a prominent feature of immunopathology. Compelling evidence has indicated a key function of BAFF in driving autoreactive B cell response during autoimmune progression. Recent clinical studies have demonstrated BAFF as a therapeutic target in various ADs. Here, we review recent findings on BAFF expression and its effector mechanisms in autoimmune pathogenesis as well as newly developed therapeutic targeting of BAFF in the treatment of ADs.
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