炎症体
生物
吡喃结构域
胞浆
细胞生物学
生物物理学
计算生物学
生物化学
受体
酶
作者
Kate Schroder,Rebecca C. Coll
出处
期刊:Cell
[Elsevier]
日期:2021-12-01
卷期号:184 (26): 6224-6226
被引量:2
标识
DOI:10.1016/j.cell.2021.11.035
摘要
How the danger sensor NLRP3 is activated is intensively debated. Using cryo-electron microscopy (EM) approaches, Andreeva and colleagues made the remarkable discovery that inactive NLRP3 forms a double ring of 12-16 monomers that shield its pyrin domains from the cytosol. We discuss this surprising new mechanism of inflammasome regulation.
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