表观遗传学
生物
DNA损伤
组蛋白
Gadd45型
细胞生物学
DNA修复
DNA甲基化
转录因子
细胞周期
神经科学
细胞周期检查点
遗传学
基因
基因表达
DNA
作者
Faraz Sultan,Bassel E. Sawaya
标识
DOI:10.1007/978-3-030-94804-7_9
摘要
The growth arrest and DNA damage-inducible (Gadd) 45 proteins have been associated with numerous cellular mechanisms including cell cycle control, DNA damage sensation and repair, genotoxic stress, neoplasia, and molecular epigenetics. The genes were originally identified in in vitro screens of irradiation- and interleukin-induced transcription and have since been implicated in a host of normal and aberrant central nervous system processes. These include early and postnatal development, injury, cancer, memory, aging, and neurodegenerative and psychiatric disease states. The proteins act through a variety of molecular signaling cascades including the MAPK cascade, cell cycle control mechanisms, histone regulation, and epigenetic DNA demethylation. In this review, we provide a comprehensive discussion of the literature implicating each of the three members of the Gadd45 family in these processes.
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