声动力疗法
上睑下垂
活性氧
癌细胞
化学
癌症
癌症研究
细胞凋亡
医学
生物化学
程序性细胞死亡
内科学
作者
Yu Zhu,Wenlong Cao,Chuangye Han,Zhen Wang,Yue Qiu,Jiancheng Wang,Mengda Wei,Junfu Wang,Siwen Zhang,Senfeng Liu,Shutian Mo,Junqiang Chen
标识
DOI:10.3389/fbioe.2022.796820
摘要
In recent years, sonodynamic therapy (SDT) has been widely developed for cancer research as a promising non-invasive therapeutic strategy. Here, we synthesized zeolitic imidazole frameworks-8 (ZIF-8) and utilized its properties to encapsulate hydrophobic Chlorin e6 (Ce6) and hydrophilic tirapazamine (TPZ) for a synergistic sonodynamic chemotherapy, which was also accompanied by the modification of cytomembrane of gastric cancer (GC) cells. Thus, we enabled the biomimetic property to achieve targeted delivery. Ce6-mediated SDT, in combination with ultrasound irradiation, could target the release of reactive oxygen species (ROS) to aggravate further hypoxia and activate TPZ. Combining these effects could induce the pyroptosis of GC cells and play the anti-tumor function, which could provide a potential therapeutic method for cancer therapy.
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