电化学发光
双金属
纳米棒
材料科学
双金属片
电导率
兴奋剂
纳米技术
导电体
电阻率和电导率
发光体
金属有机骨架
光电子学
生物传感器
电极
金属
发光
化学
电气工程
复合材料
工程类
物理化学
吸附
有机化学
冶金
作者
Yang Yang,Jialing Zhang,Wenbin Liang,Jinling Zhang,Xinzheng Xu,Yongjiang Zhang,Ruo Yuan,Dong‐Rong Xiao
标识
DOI:10.1016/j.snb.2022.131802
摘要
Metal-organic frameworks (MOFs) has recently attracted immense attention in electrochemiluminescence (ECL) field, yet the ECL performance of MOFs is largely limited by their natively poor electric conductivity (generally < 10−8S m−1). To address this drawback, we adopted the doping strategy to synthesize a conductive bimetallic MOF nanorod [NixCo9-x(HHTP)4(H2O)30] (denoted as NiCo-HHTP, HHTP = 2,3,6,7,10,11-hexahydroxytriphenylene) with excellent electrical conductivity (1.20 × 10−3S m−1), which could accelerate the charge transport and facilitate the electrochemical activation of HHTP luminophore, thereby improving utilization ratio of ECL luminophores to achieve a strong ECL emission. As expected, our experiment showed that the bimetallic NiCo-HHTP was superior to the isostructural monometallic MOF (Ni-HHTP) with nearly 2.82-fold higher electrical conductivity, 2.06-fold higher ECL intensity and 3.39-fold higher ECL efficiency. These results suggested that the electrical conductivity of NiCo-HHTP could be significantly improved by doping with cobalt, and the outstanding electrical conductivity greatly contributed to its excellent ECL performance. Considering the above-mentioned superior ECL properties, the NiCo-HHTP nanorods were utilized to fabricate an ultrasensitive ECL biosensor for microRNA-141 determination, achieving a wide linear range from 1 fM to 10 nM and a low detection limit of 0.69 fM. Overall, our work proposed a hopeful and practicable strategy to improve ECL performance via enhancing electrical conductivity of MOFs, which overcame current limitation of ECL enhancement in nonconductive MOFs and opened a new chapter to prepare high-efficiency MOF-based ECL materials, thus providing a unique opportunity for constructing ultrasensitive ECL sensors.
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