CD47型
吞噬作用
巨噬细胞
化学
体内
免疫系统
细胞生物学
体外
抗体
单克隆抗体
间隙
癌细胞
生物化学
癌症
免疫学
生物
医学
遗传学
生物技术
泌尿科
作者
AbdelAziz R Jalil,Michael P. Tobin,Dennis E. Discher
标识
DOI:10.1021/acs.bioconjchem.2c00019
摘要
Foreign particles and microbes are rapidly cleared by macrophages in vivo, although many key aspects of uptake mechanisms remain unclear. "Self" cells express CD47 which functions as an anti-phagocytic ligand for SIRPα on macrophages, particularly when pro-phagocytic ligands such as antibodies are displayed in parallel. Here, we review CD47 and related "Self" peptides as modulators of macrophage uptake. Nanoparticles conjugated with either CD47 or peptides derived from its SIRPα binding site can suppress phagocytic uptake by macrophages in vitro and in vivo, with similar findings for CD47-displaying viruses. Drugs, dyes, and genes as payloads thus show increased delivery to targeted cells. On the other hand, CD47 expression by cancer cells enables such cells to evade macrophages and immune surveillance. This has motivated development of soluble antagonists to CD47-SIRPα, ranging from blocking antibodies in the clinic to synthetic peptides in preclinical models. CD47 and peptides are thus emerging as dual-use phagocytosis modulators against diseases.
科研通智能强力驱动
Strongly Powered by AbleSci AI