废止
对映选择合成
全合成
环加成
立体化学
分子内力
烯烃
化学
羟醛反应
天然产物
组合化学
有机化学
催化作用
作者
Hongxiu Huang,Fen Mi,Chunxin Li,Huan He,Feng‐Peng Wang,Xiaoyu Liu,Yong Qin
标识
DOI:10.1002/ange.202011923
摘要
Abstract The first total synthesis of liangshanone, a hexacyclic ent ‐kaurane diterpenoid alkaloid, has been completed. Its intricate cagelike framework was assembled through several key transformations, including an oxidative dearomatization/Diels–Alder (OD/DA) cycloaddition sequence, a tandem alkene cleavage/Mannich cyclization, a Robinson‐type annulation, and an intramolecular aldol reaction. Notably, an organocatalytic enantioselective α‐hydroxymethylation process allowed the preparation of an enantiomerically enriched tricyclic intermediate that should enable asymmetric access to the target natural product.
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