染色质
泛素
细胞生物学
组蛋白
抄写(语言学)
蛋白质亚单位
蛋白酶体
生物
基因
遗传学
化学
语言学
哲学
作者
Craig A. Mizzen,C. David Allis
出处
期刊:Science
[American Association for the Advancement of Science (AAAS)]
日期:2000-09-29
被引量:28
标识
DOI:10.1126/science.289.5488.2290
摘要
It has been well established that tagging proteins with ubiquitin targets them for degradation in the proteasome pathway. However, as [Mizzen and Allis][1] comment in their Perspective, now it turns out that the addition of ubiquitin to the H1 linker histone in chromatin contributes to the regulation of gene transcription. The TAF250 subunit of Drosophila TFIID has ubiquitinating activity. By adding ubiquitin to H1, it may act in concert with other modifying activities to enhance the accessibility of chromatin to transcription complexes, thus regulating which genes are transcribed.
[1]: http://www.sciencemag.org/cgi/content/full/289/5488/2290
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