劈理(地质)
药物化学
有机化学
碳-碳键
有机合成
作者
You Zhou,Peng Zhao,Li-Sheng Wang,Xiao-Xiao Yu,Chun Huang,Yan-Dong Wu,An-Xin Wu
出处
期刊:Organic Letters
[American Chemical Society]
日期:2021-08-04
卷期号:23 (16): 6461-6465
被引量:4
标识
DOI:10.1021/acs.orglett.1c02267
摘要
A novel [2 + 1 + 3] cyclization reaction for the synthesis of 2-aryl-4-quinolinecarboxylates from aryl methyl ketones, arylamines, and 1,3-dicarbonyl compounds has been established. This metal-free process achieved the C-C bond cleavage of 1,3-dicarbonyl compounds directly as a single-carbon synthon. The reaction is highly efficient and has good substrate compatibility while operating under mild conditions. This method has good practicability and successfully realized the synthesis of bioactive molecules.
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