What to do with unusual TDP‐43 proteinopathy cases?

LATE‐NC is a diagnostic term developed by a large, multidisciplinary, international team of experts, after months of discussion and a NIH‐funded 2 day in‐person meeting in late 2018. This group was tasked with generating suitable terminology for common TDP‐43 proteinopathy in aging. When diagnosing an unusual case of TDP‐43 proteinopathy at autopsy, a diagnostic approach is recommended that is analogous to unusual tauopathy or α‐synucleinopathy cases: render a descriptive neuropathologic diagnosis, rather than label such cases as LATE‐NC.