脂肪生成
脂肪性肝炎
胰岛素抵抗
甘油三酯
内分泌学
内科学
体内
脂肪变性
脂质代谢
碳水化合物反应元件结合蛋白
胰岛素
脂肪肝
化学
生物
医学
生物化学
基因
胆固醇
转录因子
生物技术
疾病
作者
Irma Catalina Soto-Luna,P. M. García-López,Belinda Vargas-Guerrero,Tereso J. Guzmán,José Alfredo Domı́nguez-Rosales,Carmen M. Gurrola-Díaz
摘要
Abstract Although studies on lupin protein isolate (LPI) have indicated the presence of a preventive effect on insulin resistance (IR) and lipid disturbances, their influence on established pathological traits has received little attention. Here, we evaluated the in vivo effects of LPI on IR and steatohepatitis as well as its influence on genes involved in lipid and carbohydrate metabolism. We first induced IR and steatohepatitis in rats by maintaining them on a high‐fat diet for 5 weeks. Thereafter, we administered LPI to the rats daily for 3 weeks. LPI improved insulin sensitivity (AUC: 6,777 ± 232 vs. 4,971 ± 379, p < .05, pre‐ vs. post‐treatment values) and reduced glucose and triglyceride levels by one‐third. In addition, LPI‐treated rats exhibited attenuated steatohepatitis. At the molecular level, LPI treatment reduced liver Fasn gene expression substantially but increased Gys2 and Gsk3b levels. We concluded that the hypolipidemic and hypoglycemic activities of LPI may be caused by reduced liver lipogenesis and modulation of insulin sensitization mechanisms.
科研通智能强力驱动
Strongly Powered by AbleSci AI