A Stepwise Targeting and Antibacterial Strategy by Leukocyte Membrane-Based Conjugated Oligomer Nanoparticles

Bacterial infection poses an enormous threat to human life and health. The inability of drugs to be effectively delivered to the site of infection and the development of bacterial resistance make the treatment process more difficult. Herein, a stepwise targeted biomimetic nanoparticle (NPs@M-P) with inflammatory tendency and Gram-negative bacterial targeting was designed, which can achieve efficient antibacterial activity under near-infrared triggering. Leukocyte membranes and targeted molecules (PMB) are used to deliver NPs to the surface of Gram-negative bacteria. The heat and ROS released by NPs@M-P can efficiently kill Gram-negative bacteria under low-power near-infrared light. Thus, this multimodal combination therapy strategy has broad promise in fighting bacterial infection and avoiding drug resistance.