材料科学
表面等离子共振
氯金酸
等离子体子
肉眼
琼脂糖
纳米技术
纳米颗粒
蚀刻(微加工)
壳体(结构)
检出限
胶体金
光电子学
化学
图层(电子)
色谱法
复合材料
作者
Jianjun Yi,Zexiang Wang,Jing Hu,Ting Yu,Yidan Wang,Pengfei Ge,Yunlei Xianyu
标识
DOI:10.1021/acsami.3c02440
摘要
Antioxidants are crucial for human health, and the detection of antioxidants can provide valuable information for disease diagnosis and health management. In this work, we report a plasmonic sensing approach for the determination of antioxidants based on their antietching capacity toward plasmonic nanoparticles. The Ag shell of core–shell Au@Ag nanostars can be etched by chloroauric acid (HAuCl4), whereas antioxidants can interact with HAuCl4, which prevents the surface etching of Au@Ag nanostars. We modulate the thickness of the Ag shell and morphology of the nanostructures, showing that the core–shell nanostars with the smallest thickness of Ag shell have the best etching sensitivity. Owing to the extraordinary surface plasmon resonance (SPR) property of Au@Ag nanostars, the antietching effect of antioxidants can induce a significant change in both the SPR spectrum and the color of solution, facilitating both the quantitative detection and naked-eye readout. This antietching strategy enables the determination of antioxidants such as cystine and gallic acid with a linear range of 0.1–10 μM. The core–shell Au@Ag nanostars are further immobilized in agarose gels to fabricate test strips, which can display different color changes in the presence of HAuCl4 from 0 to 1000 μM. The agarose-based test strip is also capable of detecting antioxidants in real samples, which allows naked-eye readout and quantitative detection by a smartphone.
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