Click Chemistry: Current Applications and Future Potential in Addressing Complex Scientific Challenge

Objective: Click chemistry has rapidly gained prominence as a powerful tool in chemistry, enabling precise interaction, isolation, and targeting of molecular domains within complex biological systems. Its sensitivity and specificity confer significant biological relevance, making it a promising area for ongoing scientific exploration. This study aims to (a) highlight the key features of click chemistry, (b) review its current applications, (c) discuss the scientific challenges it addresses, and (d) explore its future potential. Materials and Methods: A systematic literature review was conducted on studies published between 1995 and 2025. Data synthesis followed the PRISMA guidelines, and the quality of evidence was assessed using the GRADE criteria. The review focuses on the current and future potential of click chemistry. Results: Click chemistry facilitates the rapid synthesis of numerous compounds with high reliability in chemical and practical transformations. It has significantly expanded the horizons of chemical synthesis, particularly in drug discovery, bioconjugation, and diagnostics. Despite some limitations, its adaptability and efficiency establish click chemistry as a valuable problem-solving Conclusion: The future of chemical synthesis will be shaped by advancing our understanding and applications of click chemistry. Its impact spans diverse fields, including lead drug discovery, carbohydrate chemistry, natural product synthesis, and macromolecular polymer synthesis.