Silicon Incorporated Tacrine: Design, Synthesis, and Evaluation of Biological and Pharmacokinetic Parameters
塔克林
药代动力学
组合化学
化学
计算机科学
药理学
有机化学
医学
乙酰胆碱酯酶
酶
作者
Akshay S. Kulkarni,Sreenivasa Rao Ramana,Vijay K. Nuthakki,Shipra Bhatt,Ashiya Jamwal,Laxman D. Nandawadekar,Anshika Jotshi,Ajay Kumar,Utpal Nandi,Sandip B. Bharate,D. Srinivasa Reddy
We report a silicon-incorporated tacrine and assess its cholinesterase inhibitory activity, in vitro metabolic stability, and brain/plasma pharmacokinetic profile.
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(2025-6-4)
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