材料科学
胶粘剂
自愈水凝胶
粘附
丙烯酸
聚合物
生物粘附
多巴胺
丙烯酸酯
光致聚合物
高分子化学
共价键
复合材料
化学工程
聚合
有机化学
化学
单体
图层(电子)
神经科学
工程类
生物
作者
Gi‐Yeon Han,Ji‐Yong Park,Tae‐Hyung Lee,Mo‐Beom Yi,Seungman Kim
标识
DOI:10.1021/acsami.2c04791
摘要
Hydrogels are promising material for wound dressing and tissue engineering. However, owing to their low tissue adhesion in a moist environment and lack of flexibility, hydrogels are still not widely applied in movable parts, such as joints. Herein, we report a dual-crosslinked hydrogel adhesive using a dopamine-modified and acrylate-terminated crosslinker, tri(ethylene glycol) diacrylate-dopamine crosslinker (TDC). The covalent crosslinking was formed by photopolymerization between acrylic acid (AA) and TDC, and the noncovalent crosslinking was formed by intermolecular dopamine–dopamine and dopamine–AA interactions. Our resultant hydrogel demonstrated strong tissue adhesion in a moist environment (approximately 71 kPa) and high mechanical resilience (approximately 94%) with immediate recovery at a 200% strain rate. Moreover, it accelerated wound healing upon dressing the wound site properly. Our study provides the potential for advanced polymer synthesis by introducing a functional crosslinking agent.
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