Unilateral heliotrope rash: A call for recognizing its warning significance in anti‐MDA5 antibody‐associated dermatomyositis

The Journal of DermatologyEarly View LETTER TO THE EDITOR Unilateral heliotrope rash: A call for recognizing its warning significance in anti-MDA5 antibody-associated dermatomyositis Deyu Song, Deyu Song orcid.org/0000-0001-9514-0740 Department of Dermatology, West China Hospital, Sichuan University, Chengdu, China Laboratory of Dermatology, Clinical Institute of Inflammation and Immunology, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, Sichuan University, Chengdu, ChinaSearch for more papers by this authorQin Yi, Qin Yi Department of Dermatology, West China Hospital, Sichuan University, Chengdu, ChinaSearch for more papers by this authorKaiwen Zhuang, Kaiwen Zhuang orcid.org/0000-0002-1376-6385 Department of Dermatology, West China Hospital, Sichuan University, Chengdu, ChinaSearch for more papers by this authorLi Yang, Li Yang Department of Dermatology, Ningxia Fifth People's Hospital, Shizuishan, ChinaSearch for more papers by this authorDan Du, Dan Du Department of Dermatology, West China Hospital, Sichuan University, Chengdu, China Laboratory of Dermatology, Clinical Institute of Inflammation and Immunology, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, Sichuan University, Chengdu, ChinaSearch for more papers by this authorXian Jiang, Corresponding Author Xian Jiang [email protected] orcid.org/0000-0001-5109-6055 Department of Dermatology, West China Hospital, Sichuan University, Chengdu, China Laboratory of Dermatology, Clinical Institute of Inflammation and Immunology, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, Sichuan University, Chengdu, China Correspondence Xian Jiang, Department of Dermatology, West China Hospital, Sichuan University, 37 Guoxue Alley, Wuhou District, Chengdu 610041, China. Email: [email protected]Search for more papers by this author Deyu Song, Deyu Song orcid.org/0000-0001-9514-0740 Department of Dermatology, West China Hospital, Sichuan University, Chengdu, China Laboratory of Dermatology, Clinical Institute of Inflammation and Immunology, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, Sichuan University, Chengdu, ChinaSearch for more papers by this authorQin Yi, Qin Yi Department of Dermatology, West China Hospital, Sichuan University, Chengdu, ChinaSearch for more papers by this authorKaiwen Zhuang, Kaiwen Zhuang orcid.org/0000-0002-1376-6385 Department of Dermatology, West China Hospital, Sichuan University, Chengdu, ChinaSearch for more papers by this authorLi Yang, Li Yang Department of Dermatology, Ningxia Fifth People's Hospital, Shizuishan, ChinaSearch for more papers by this authorDan Du, Dan Du Department of Dermatology, West China Hospital, Sichuan University, Chengdu, China Laboratory of Dermatology, Clinical Institute of Inflammation and Immunology, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, Sichuan University, Chengdu, ChinaSearch for more papers by this authorXian Jiang, Corresponding Author Xian Jiang [email protected] orcid.org/0000-0001-5109-6055 Department of Dermatology, West China Hospital, Sichuan University, Chengdu, China Laboratory of Dermatology, Clinical Institute of Inflammation and Immunology, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, Sichuan University, Chengdu, China Correspondence Xian Jiang, Department of Dermatology, West China Hospital, Sichuan University, 37 Guoxue Alley, Wuhou District, Chengdu 610041, China. Email: [email protected]Search for more papers by this author First published: 15 April 2024 https://doi.org/10.1111/1346-8138.17228Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat No abstract is available for this article. REFERENCES 1Kurtzman DJB, Vleugels RA. Anti-melanoma differentiation-associated gene 5 (MDA5) dermatomyositis: a concise review with an emphasis on distinctive clinical features. J Am Acad Dermatol. 2018; 78: 776–85. 10.1016/j.jaad.2017.12.010 CASPubMedWeb of Science®Google Scholar 2Fiorentino D, Chung L, Zwerner J, Rosen A, Casciola-Rosen L. The mucocutaneous and systemic phenotype of dermatomyositis patients with antibodies to MDA5 (CADM-140): a retrospective study. J Am Acad Dermatol. 2011; 65: 25–34. 10.1016/j.jaad.2010.09.016 PubMedWeb of Science®Google Scholar 3Kume M, Arase N, Okiyama N, Koguchi-Yoshioka H, Tada T, Saruban H, et al. Unilateral heliotrope rash: a warning sign for anti-melanoma differentiation-associated gene 5 antibody-positive dermatomyositis. Rheumatology (Oxford). 2021; 60: e134–5. 10.1093/rheumatology/keaa574 PubMedWeb of Science®Google Scholar 4Lam SC, Yuen HKL. Unilateral eyelid swelling as a sign of antimelanoma differentiation-associated gene 5 (anti-MDA5)-antibody-positive dermatomyositis. Ophthal Plast Reconstr Surg. 2018; 34: e209–11. 10.1097/IOP.0000000000001258 PubMedWeb of Science®Google Scholar 5Jablonski R, Bhorade S, Strek ME, Dematte J. Recognition and management of myositis-associated rapidly progressive interstitial lung disease. Chest. 2020; 158: 252–63. 10.1016/j.chest.2020.01.033 PubMedWeb of Science®Google Scholar Early ViewOnline Version of Record before inclusion in an issue ReferencesRelatedInformation