CARTILAGE PROTECTIVE AND ANTI-EDEMA EFFECTS OF JIANPI-TONGLUO FORMULA IN OSTEOARTHRITIS VIA INHIBITING NCOA4-HMGB1-DRIVEN FERROPTOSIS AND AQUAPORIN DYSREGULATION

Purpose (the aim of the study): Reducing joint edema has been indicated as an effective way to prevent the progression of osteoarthritis (OA). Accumulating clinical practices have revealed that a Chinese herbal prescription Jianpi-Tongluo Formula (JPTLF) may have notable efficacy in reducing edema. However, its therapeutic properties and mechanisms remain unclear. Herein, we aimed to detect corresponding therapeutic characteristics and potential pharmacological mechanisms.