Prediction of Atrial Arrhythmia after Allogenic Transplantation Using Artificial Intelligence-Enabled ECG

NKG2D is a major activation receptor on natural killer (NK) cells and a unique receptor on Cd8 T cells and subsets of NKT and γδ T cells. NKG2D is generally absent on CD4 T cells. The ligand of NKG2D (NKG2D-L) is generally absent on normal tissues, but prevalently induced on tumors cells as a response to genomic insults. Due to the unique nature of the NKG2D/NKG2D-L axis, attentions and efforts are emerging to harness the power of NKG2D/NKG2D-L for cancer immunotherapy. To support this development, this chapter will cover the basic biology of the NKG2D/NKG2D-L system and strategies to target this axis for cancer immunotherapy.