肌萎缩性肥胖
肌萎缩
医学
肥胖
生活质量(医疗保健)
病因学
重症监护医学
瘦体质量
肌肉团
生物信息学
内科学
体重
生物
护理部
作者
Christopher L. Axelrod,Wagner Silva Dantas,John P. Kirwan
标识
DOI:10.1016/j.metabol.2023.155639
摘要
Sarcopenic obesity, or the loss of muscle mass and function associated with excess adiposity, is a largely untreatable medical condition associated with diminished quality of life and increased risk of mortality. To date, it remains somewhat paradoxical and mechanistically undefined as to why a subset of adults with obesity develop muscular decline, an anabolic stimulus generally associated with retention of lean mass. Here, we review evidence surrounding the definition, etiology, and treatment of sarcopenic obesity with an emphasis on emerging regulatory nodes with therapeutic potential. We review the available clinical evidence largely focused on diet, lifestyle, and behavioral interventions to improve quality of life in patients with sarcopenic obesity. Based upon available evidence, relieving consequences of energy burden, such as oxidative stress, myosteatosis, and/or mitochondrial dysfunction, is a promising area for therapeutic development in the treatment and management of sarcopenic obesity.
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