溃疡性结肠炎
化学
抗氧化剂
多酚
马齿苋
分子质量
多糖
结肠炎
功能性食品
抗氧化能力
食品科学
生物化学
传统医学
生物
医学
免疫学
酶
病理
疾病
作者
Ke Ning,Yanmin Duan,Weiwei Tong,Yue Chen,Qinghui Zhang,Qiuhong Xie,Qiuhong Xie
出处
期刊:Antioxidants
[MDPI AG]
日期:2023-07-08
卷期号:12 (7): 1400-1400
被引量:3
标识
DOI:10.3390/antiox12071400
摘要
Purslane, a common wild vegetable, contains active substances with various biological functions. However, its effects have been under-investigated in ulcerative colitis (UC). Therefore, this study investigated the therapeutic effects of purslane macromolecular (POEM) and small molecular extracts (POES) on dextran sulfate sodium (DSS)-induced UC in mice. Membrane separation was used to obtain extracts of different molecular weights, and their compositional differences were compared using liquid chromatography-mass spectrometry (LC/MS). POEM contained more proteins and polysaccharides, whereas POES contained more organic acids and alkaloids. These differences in composition were directly responsible for the different degrees of remission of the alleviated UC in model mice. POEM may alleviate UC by regulating the antioxidant capacity and the gut microbiota, whereas the major alleviatory effect of POES was primarily related to the regulation of antioxidant capacity. The POEM and POES effects identified in this study provide a theoretical basis for the development of purslane as a functional food.
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