Green acetyl modification of puerarin to form puerarin 6′′-O-acetate using the engineered Escherichia coli harboring favorable pathways elevating acetyl-CoA supply

Puerarin 6′′-O-acetate (P6′′A), a puerarin derivative with high stability and improved permeability, exhibiting a promising potential in drug development. The large-scale production of P6′′A through green synthesis procedures had never...