乳腺癌
转移
脑转移
癌症研究
微泡
癌症
细胞外小泡
信号转导
生物
医学
病理
内科学
细胞生物学
小RNA
生物化学
基因
作者
Yuima Sakamoto,Takahiro Ochiya,Yusuke Yoshioka
标识
DOI:10.3389/fnhum.2023.1278501
摘要
Breast cancer, which exhibits an increasing incidence and high mortality rate among cancers, is predominantly attributed to metastatic malignancies. Brain metastasis, in particular, significantly contributes to the elevated mortality in breast cancer patients. Extracellular vesicles (EVs) are small lipid bilayer vesicles secreted by various cells that contain biomolecules such as nucleic acids and proteins. They deliver these bioactive molecules to recipient cells, thereby regulating signal transduction and protein expression levels. The relationship between breast cancer metastasis and EVs has been extensively investigated. In this review, we focus on the molecular mechanisms by which EVs promote brain metastasis in breast cancer. Additionally, we discuss the potential of EV-associated molecules as therapeutic targets and their relevance as early diagnostic markers for breast cancer brain metastasis.
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