RBM39: A druggable metabolic sensor linking RNA splicing, transcriptional regulation, and metabolic reprogramming in cancer

In a recent issue of Cell, Mossmann et al. 1 Mossmann D. Müller C. Park S. Ryback B. Colombi M. Ritter N. Weißenberger D. Dazert E. Coto-Llerena M. Nuciforo S. et al. Arginine reprograms metabolism in liver cancer via RBM39. Cell. 2023; 186: 5068-5083.e23https://doi.org/10.1016/j.cell.2023.09.011 Google Scholar describe a novel role for an emerging cancer target, RNA-binding motif protein 39, as a metabolic sensor of the conditionally essential amino acid arginine. In a recent issue of Cell, Mossmann et al. 1 Mossmann D. Müller C. Park S. Ryback B. Colombi M. Ritter N. Weißenberger D. Dazert E. Coto-Llerena M. Nuciforo S. et al. Arginine reprograms metabolism in liver cancer via RBM39. Cell. 2023; 186: 5068-5083.e23https://doi.org/10.1016/j.cell.2023.09.011 Google Scholar describe a novel role for an emerging cancer target, RNA-binding motif protein 39, as a metabolic sensor of the conditionally essential amino acid arginine. Arginine reprograms metabolism in liver cancer via RBM39Mossmann et al.CellOctober 6, 2023In BriefArginine is a second messenger-like molecule that promotes liver tumorigenesis by binding to RBM39 and controlling metabolic gene expression. RBM39 depletion by the molecular glue degrader indisulam blocks pro-oncogenic metabolic reprogramming in hepatocellular carcinoma, suggesting that RBM39 is a therapeutic target in liver cancer. Full-Text PDF Open Access