Rejuvenating muscle stem cells with the glutathione system

Aging results from the combination of complex processes still largely undefined. In this issue, Benjamin et al. use multiomic analysis to reveal a causative role of altered glutathione (GSH) synthesis and metabolism in age-dependent muscle stem cell (MuSC) dysfunction, casting light on novel mechanisms regulating stem cell function and on therapeutic approaches to improve defective regeneration in the aged muscle. Aging results from the combination of complex processes still largely undefined. In this issue, Benjamin et al. use multiomic analysis to reveal a causative role of altered glutathione (GSH) synthesis and metabolism in age-dependent muscle stem cell (MuSC) dysfunction, casting light on novel mechanisms regulating stem cell function and on therapeutic approaches to improve defective regeneration in the aged muscle. Multiomics reveals glutathione metabolism as a driver of bimodality during stem cell agingBenjamin et al.Cell MetabolismFebruary 27, 2023In BriefThis study uses a multiomic analysis to uncover a novel mechanism that underlies stem cell aging. Benjamin et al. report how GSH metabolism is altered with age in a bimodal manner, creating two functionally distinct metabolic subpopulations of aged cells. Full-Text PDF