孟德尔随机化
全基因组关联研究
优势比
牙周炎
医学
单核苷酸多态性
置信区间
骨矿物
多效性
遗传关联
内科学
骨质疏松症
遗传学
生物
基因型
遗传变异
基因
表型
作者
Zoheir Alayash,Sebastian‐Edgar Baumeister,Stefan Lars Reckelkamm,Birte Holtfreter,Thomas Kocher,Hansjörg Baurecht,Benjamin Ehmke,Michael Nolde
摘要
The purpose of the study was to examine the association between total body bone mineral density (BMD) and periodontitis using Mendelian randomization (MR) analysis.We used 81 single nucleotide polymorphisms (SNPs) associated with BMD at a p-value of < 5 × 10-8 from a genome-wide association study (GWAS) of 66,628 individuals of European descent. The GWAS for periodontitis was derived from a meta-analysis of seven cohort studies that included 17,353 cases and 28,210 controls of European ancestry.MR showed no association between BMD and periodontitis (odds ratio per standard deviation increment in genetically predicted BMD = 1.00; 95% confidence interval: 0.92-1.08). Leave-one-out analyses and pleiotropy-robust methods did not indicate any bias.The MR study provided no evidence that BMD might be causally linked to periodontitis. Hence it may be concluded as the key finding that BMD depletion does not increase the risk of periodontitis.
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