淋巴系统
旁分泌信号
血管内皮生长因子受体
肾
淋巴管内皮
癌症研究
生物
医学
细胞生物学
病理
受体
内分泌学
内科学
作者
Michael D. Donnan,Dilip K. Deb,Tuncer Onay,Rizaldy P. Scott,Eric Ni,Yalu Zhou,Susan E. Quaggin
出处
期刊:American Journal of Physiology-renal Physiology
[American Physiological Society]
日期:2023-01-01
卷期号:324 (1): F91-F105
被引量:5
标识
DOI:10.1152/ajprenal.00066.2022
摘要
Targeting VEGFR-3 in kidney lymphatics has been proposed as a method to treat kidney disease. However, expression of VEGFR-3 is not lymphatic-specific. We demonstrated developmental expression of VEGFR-3 in glomerular endothelial cells, with loss of Vegfr-3 leading to malformation of glomerular capillary loops. Furthermore, we showed that VEGFR-3 attenuates VEGFR-2 activity in glomerular endothelial cells independent of paracrine VEGF-C signaling. Together, these data provide valuable information for therapeutic development targeting these pathways.
科研通智能强力驱动
Strongly Powered by AbleSci AI