Social defeat stress aggravates asthma airway inflammation through neutrophils

BACKGROUNDS: Psychological stress is a recognized contributor to asthma progression and is associated with increased neutrophils. OBJECTIVE: To investigate the role of neutrophils and NETosis in psychosocial stress aggravates asthma airway inflammation. METHODS: , impaired NETosis) mice were used to explore neutrophil-driven mechanisms. RESULTS: ) mitigated the SDS-induced asthma hyperresponsiveness and inflammation. CONCLUSIONS: Neutrophils and NETosis are critical mediators of SDS-induced asthma airway hyperresponsiveness, inflammation and mucus hypersecretion, highlighting potential therapeutic targets.