Pepsin, trypsin, and MUC5B are independent risk factors for hearing impairment in patients with laryngopharyngeal reflux-related chronic secretory otitis media

Pepsin, trypsin, and MUC5B are independent risk factors for hearing impairment in LPR-related CSOM patients. Their combination assists hearing impairment diagnosis in patients, providing a tool in clinical practice to stratify patients and offering a theoretical basis for exploring therapeutic targets.