The Role of Migrasomes in Health and Disease

Migrasomes are specialized organelles that form during cell migration and play a critical role in intercellular communication and disease progression. First discovered in 2012 and reported in 2015, these organelles are characterized by their unique biogenesis on retraction fibers and their role in spatiotemporal signaling, distribution of bioactive molecules, and maintenance of cellular homeostasis. This review provides a comprehensive overview of migrasome biology, exploring their discovery, mechanisms of formation, physiological functions, and pathological implications. We examine their dual roles in both health and disease, highlighting their potential as diagnostic biomarkers and therapeutic targets. Additionally, we discuss the challenges and future directions in migrasome research, emphasizing the importance of foundational discoveries and advanced methodologies to fully realize their clinical potential.