激光器
微束
通量
皮秒
体内
真皮
表皮(动物学)
材料科学
脉搏(音乐)
生物医学工程
生物物理学
化学
病理
光学
解剖
医学
核医学
生物
生物技术
物理
探测器
作者
Justinas Baleišis,Romualdas Rudys
标识
DOI:10.1002/jbio.202200349
摘要
The fractionated picosecond laser produces microscopic lesions in the epidermis and dermis due to laser-induced optical breakdown (LIOB). There have been multiple histological reports, but the present literature lacks detailed in vivo studies after treatment with high-power laser systems. Our study aimed to characterize the healing patterns of microlesions induced with 150 ps duration 1064 nm MLA-type picosecond laser. The induced picosecond laser-tissue reactions with pulse energy of 50-250 mJ and different treatment modes were observed in in vivo porcine skin model over 10 days after the laser procedure. A macroscopic evaluation was combined with microscopic histological analysis to observe the healing dynamics of laser-induced microlesions. Superficial, intraepidermal cavitation bubbles were induced using microbeam fluence of 4-20 J/cm2 . Skin irritation scores positively correlated with pulse energy and dose. Our findings demonstrate that dose and pulse energy had a direct impact on epidermal thickness and lesions healing dynamics.
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