Microinjection in Biomedical Applications: An Effortless Autonomous Omnidirectional Microinjection System

Thanks to the advancements in micro- and nanomechatronics techniques, the capability to inject foreign materials into target locations inside biosamples has become increasingly crucial. However, technical problems, like orientation and penetration, make manual microinjection challenging, while most available automated platforms are too targeted and often fail to support reconfiguration for different injection tasks. In this article, we first review the state-of-the-art in microinjection techniques for biomedical applications. Then, to solve the aforementioned problems, we report an autonomous omnidirectional microinjection (AOM) system based on effortless updates of manual injection hardware with experiments. Future perspectives on the system are outlined with the possibility of multiplying daily genetic screens and the potential of widespread usage in laboratories and clinics.