抵抗性
污染物
基因组
微粒
环境科学
大气(单位)
环境化学
空气污染物
人类健康
空气污染
抗生素耐药性
生物
抗生素
环境卫生
生态学
微生物学
化学
气象学
遗传学
地理
整合子
基因
医学
作者
Min Gao,Qi Zhang,Chaotang Lei,Tao Lu,Haifeng Qian
标识
DOI:10.1016/j.scitotenv.2023.165942
摘要
The atmosphere is an important reservoir and habitat for antibiotic resistance genes (ARGs) and is a main pathway to cause potential health risks through inhalation and ingestion. However, the distribution characteristics of ARGs in the atmosphere and whether they were driven by atmospheric pollutants remain unclear. We annotated 392 public air metagenomic data worldwide and identified 1863 ARGs, mainly conferring to tetracycline, MLS, and multidrug resistance. We quantified these ARG's risk to human health and identified their principal pathogenic hosts, Burkholderia and Staphylococcus. Additionally, we found that bacteria in particulate contaminated air carry more ARGs than in chemically polluted air. This study revealed the influence of typical pollutants in the global atmosphere on the dissemination and risk of ARGs, providing a theoretical basis for the prevention and mitigation of the global risks associated with ARGs.
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