肾脏疾病
炎症
透析
氧化应激
医学
尿毒症毒素
恶化
血液透析
毒性
内科学
巨噬细胞
全身炎症
尿毒症
药理学
内分泌学
生物
生物化学
体外
作者
Takuya Wakamatsu,Suguru Yamamoto,Shiori Yoshida,Ichiei Narita
出处
期刊:Toxins
[Multidisciplinary Digital Publishing Institute]
日期:2024-05-31
卷期号:16 (6): 254-254
被引量:7
标识
DOI:10.3390/toxins16060254
摘要
Cardiovascular disease (CVD) frequently occurs in patients with chronic kidney disease (CKD), particularly those undergoing dialysis. The mechanisms behind this may be related to traditional risk factors and CKD-specific factors that accelerate atherosclerosis and vascular calcification in CKD patients. The accumulation of uremic toxins is a significant factor in CKD-related systemic disorders. Basic research suggests that indoxyl sulfate (IS), a small protein-bound uremic toxin, is associated with macrophage dysfunctions, including increased oxidative stress, exacerbation of chronic inflammation, and abnormalities in lipid metabolism. Strategies to mitigate the toxicity of IS include optimizing gut microbiota, intervening against the abnormality of intracellular signal transduction, and using blood purification therapy with higher efficiency. Further research is needed to examine whether lowering protein-bound uremic toxins through intervention leads to a reduction in CVD in patients with CKD.
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