紫杉醇
卵巢癌
转移
突变
化疗
体内
肿瘤科
医学
癌症
癌症研究
内科学
生物
基因
遗传学
作者
Pengfei Yu,Chang‐Ming Hu,Guangyu Ding,Xiaoliang Shi,Jingli Xu,Yang Cao,Xiangliu Chen,Wei Wu,Qi Xu,Jingquan Fang,Xingmao Huang,Shuai Yuan,Hui Chen,Zhizheng Wang,Ling Huang,Fei Pang,Yian Du,Xiangdong Cheng
标识
DOI:10.1038/s41467-024-48144-0
摘要
Abstract Ovarian metastasis is one of the major causes of treatment failure in patients with gastric cancer (GC). However, the genomic characteristics of ovarian metastasis in GC remain poorly understood. In this study, we enroll 74 GC patients with ovarian metastasis, with 64 having matched primary and metastatic samples. Here, we show a characterization of the mutation landscape of this disease, alongside an investigation into the molecular heterogeneity and pathway mutation enrichments between synchronous and metachronous metastasis. We classify patients into distinct clonal evolution patterns based on the distribution of mutations in paired samples. Notably, the parallel evolution group exhibits the most favorable prognosis. Additionally, by analyzing the differential response to chemotherapy, we identify potential biomarkers, including SALL4 , CCDC105 , and CLDN18 , for predicting the efficacy of paclitaxel treatment. Furthermore, we validate that CLDN18 fusion mutations improve tumor response to paclitaxel treatment in GC with ovarian metastasis in vitro and vivo .
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