Dual Uncertainty-Guided Mixing Consistency for Semi-Supervised 3D Medical Image Segmentation

3D semi-supervised medical image segmentation is extremely essential in computer-aided diagnosis, which can reduce the time-consuming task of performing annotation. The challenges with current 3D semi-supervised segmentation algorithms includes the methods, limited attention to volume-wise context information, their inability to generate accurate pseudo labels and a failure to capture important details during data augmentation. This article proposes a dual uncertainty-guided mixing consistency network for accurate 3D semi-supervised segmentation, which can solve the above challenges. The proposed network consists of a Contrastive Training Module which improves the quality of augmented images by retaining the invariance of data augmentation between original data and their augmentations. The Dual Uncertainty Strategy calculates dual uncertainty between two different models to select a more confident area for subsequent segmentation. The Mixing Volume Consistency Module that guides the consistency between mixing before and after segmentation for final segmentation, uses dual uncertainty and can fully learn volume-wise context information. Results from evaluative experiments on brain tumor and left atrial segmentation shows that the proposed method outperforms state-of-the-art 3D semi-supervised methods as confirmed by quantitative and qualitative analysis on datasets. This effectively demonstrates that this study has the potential to become a medical tool for accurate segmentation. Code is available at: https://github.com/yang6277/DUMC .