Evaluation of the therapeutic role of allopurinol on bisphenol S gastric and renal toxicity in adult male albino rats: An in vivo study

Bisphenol S (BPS) is used as an alternative to bisphenol A (BPA) in polycarbonate plastics, epoxy resins and thermal receipt sheet manufacturing. We examined the toxic effects of BPS on gastric and renal functions, as well as the efficacy of allopurinol as a treatment. Albino rats were given only BPS (30 and 120 mg/kg BW/day), and some were treated with allopurinol prior to sacrifice. Gastric and renal specimens were evaluated histologically and immunohistochemically, and blood from the tail vein was analysed for levels of gastrin, uric acid (UA), erythropoietin and 8-deoxyguanosine (8-OHdG). Gastrin levels decreased while erythropoietin, UA and 8-OHdG levels increased significantly. The severity of gastric and renal damage observed in BPS-treated animals increased with increasing doses. The mean percentage of COX-2 immunoreactivity and the mean number of CD45 immunoreactive cells were significantly increased in the stomach and kidney of BPS rats. Allopurinol ameliorated the biochemical, histological and immunohistochemical alterations induced by BPS, with superior protection at lower doses. Allopurinol can reverse the effects of BPS on the stomach and kidneys.