Multimodal Antibacterial Platform Constructed by the Schottky Junction of Curcumin‐Based Bio Metal–Organic Frameworks and Ti3C2Tx MXene Nanosheets for Efficient Wound Healing

A novel multimodal antibacterial platform is constructed by the in situ growth of a bioactive zinc‐based metal–organic framework (Zn‐MOF) using the natural antibacterial agent (curcumin) as ligand over the Ti 3 C 2 T x nanosheets (NSs) for highly effective bacteria‐infected wound healing. As Zn nodes in Zn‐MOF can be partially exchanged by Ti sites in Ti 3 C 2 T x NSs, a novel oxygen vacancy‐rich Schottky junction is formed at the interface between Zn‐MOF and Ti 3 C 2 T x NSs, which can remarkably improve the separation and electron transfer efficiency of photoinduced carriers under near‐infrared light irradiation (808 nm). Consequently, it affords the Zn‐MOF@Ti 3 C 2 T x Schottky junction abundant superoxide radicals (•O 2 − ) and hydroxyl radicals (•OH) by electron transfer via type I mechanism and singlet oxygen ( 1 O 2 ) by energy transfer via type II mechanism, accompanying the superior photothermal performance and controllable release of Zn 2+ ions and curcumin. The Zn‐MOF@Ti 3 C 2 T x shows excellent biocompatibility and multimodal antibacterial ability toward Staphylococcus aureus and Escherichia coli . Based on the detailed investigations of the antibacterial mechanism, the Zn‐MOF@Ti 3 C 2 T x Schottky junction remarkably demonstrates accelerated wound healing (wound closure ratio is >99%) infected by S. aureus .