A Water Channel‐like Structure Self‐Assembled by Nucleosides

Abstract As artificial water channels have received widespread attention, various types of artificial water channels have been reported. However, apart from I‐quartet channels, the development of 1D water channels with water wires constructed from small molecules has rarely been reported, because of the difficulty in precisely tuning the dipolar water molecules. Inspired by G‐quartet functionalization strategies, this study explored C8 modifications of our previously reported molecule, 2‐amino‐2’‐fluoro‐2’‐deoxyadenosine (2FA), known for its strong hydration properties and self‐assembly capabilities, and investigated its potential for constructing nucleoside‐based water channel‐like structures. Among all derivatives, 2‐amino‐8‐(4‐aminophenyl)‐2’‐deoxy‐2’‐fluoro‐D‐adenosine can form an S‐shaped channel as a tetramer, incorporating water wire arrays in the solid state. Such water channel‐like structures in nucleoside self‐assemblies provide new insights into the development of novel nucleoside‐based supramolecular water channel materials.