肌腱病
末端炎
医学
平行线
病态的
物理疗法
病理
肌腱
疾病
机械工程
工程类
银屑病性关节炎
作者
Lindsay A. N. Crowe,Moeed Akbar,Robert‐Jan de Vos,Paul Kirwan,Michael Kjær,Carles Pedret,Iain B. McInnes,Stefan Siebert,Neal L. Millar
标识
DOI:10.1016/s2665-9913(23)00074-7
摘要
Tendinopathy and enthesitis share clinical, anatomical, and molecular parallels. However, their relationship is complex, presenting challenges in diagnosis and treatment. The biomechanics underlying these pathologies, together with relative immune and stromal contributions to pathology, are characterised by crucial comparative elements. However, methodologies used to study enthesitis and tendinopathy have been divergent, which could account for discrepancies in how these conditions are perceived and treated. In this Review, we summarise key clinical parallels between these two common presentations in musculoskeletal medicine and address factors that currently preclude development of more effective therapeutics. Furthermore, we describe molecular similarities and disparities that govern pathological mechanisms in tendinopathy and enthesitis, thus informing translational studies and treatment strategies.
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