The extraction condition of pomegranate polyphenols was optimized by orthogonal experiment.The effects of ethanol concentration,extraction temperature,extraction time and ratio of material to liquid on the polyphenol extraction were researched.The optimum extraction condition was as follows: ratio of pomegranate seed powder to ethanol-water(60%,volume part) 1∶20 at 60 ℃ for 1 h.Under this condition,the content of pomegranate seed polyphenol was 2.431mg/g dry matter.