Objective To observe the varieties of peripheral leukocyte count and the percent of neutrophile gyanulocyte with acute cerebral infarction patients. Methods One hundred and fifty one patients with acute cerebral infarction were divided by the area of infarction into three groups: large, middle, small area group divided by the neural default degree into three groups :low grade, moderate grade, heavy grade, record their leukocyte count and the percent of neutrophile granulocyte in blood circulation. Results The leukocyte count and the percent of neutrophile granulocyte with the group of large area cerebral infarction increased obviously(P0.01) . The leukocyte count and the percent of neutrophile granulocyte with the heavy group increase obviously(P0.01). Conclusion We can estimate morbid state by the leukocyte count and the percent of neutrophile granulocyte with acute cerebral infarction patients.