Mathematical Analysis in Assay of the Coated Tablets without Rem oved Coating

AIM]To investigate the differ ence between the assays of coated tablets with removed coating or without remove d coating. [METHODS]It was proved by mathematical analysis that the re was a theoretical differece between the assays of coated tablets with removed coating or without removed coating, under the condition of no influence of coat ing matericals on the assay. [RESULTS]After removing coating, the assaying result attenuated because of the loss of the tablet core, meanwhile th e residual coating had no influence on the assaying result. [CONCLUSION] When coating materials dont interfere with the assay of coated tablets, the direct assay without removed coating is feasible.