Effect of Point Injection Method on Gastric Mucosa Barrier in Rats with Chronic Atrophic Gastritis

OBJECTIVE To observe the effect of the point injection method on the gastric mucosa barrier in rats with chronic atrophic gastritis. METHOD Rat models with varying degrees of chronic atrophic gastritis were made using MNNG in different concentrations. Equal amounts of Huangqi Injection and Danggui Injection were mixed and injected into the point Zusanli to observe the effect of the injection on the pathological change, hexosamine of the gastric mucosa and the value of phospholipid. RESULT The indexes of the gastric mucosa damage, atrophy, metatypical hyperplasia, etc. increased with the increase of the concentration in model making. In the point injection group, marked improvement was detected in gastric mucosa damage and other related pathological changes ( P 0.01). With the increase of the concentration in model making, hexosamine and phospholipid of the gastric mucosa assumed negative correlation ( P 0.01). CONCLUSION With the increase of the severity of chronic atrophic gastritis, the values of hexosamine and phospholipid drop significantly and the function of the gastric mucosa barrier is impaired. Point injection can markedly increase the values of hexosamine and phospholipid and prevent the occurrence of chronic atrophic gastritis by reinforcing the gastric mucosa barrier.