The dynamic change of chicken serum antibody after inject IgY

This study on the dynamic change of chicken antibody after inject IgY aims to provide a guidance for clinical use of yolk antibody.50 highland gray cocks whose maternal antibody attenuated to almost disappear randomly assigned into 2 groups.The experiment group were injected with 2 mL IgY including ND-Ab,AVI-Ab H5 and AVI-Ab H9 while the control group with 2 mL Sodium Chloride.The chicken serum antibody titer was measured by hemagglutination inhibition test at different time.Results: the ND-Ab titer was significantly higher than that of control group in 1-8 day(P0.01),AVI-Ab H5 titer was significantly higher than the control group in 1-11 day(P0.01),and AVI-Ab H9 titer was significantly higher than the control group in 1-14 day(P0.01).The serum antibody titers increased significantly just 1d post injection while the high antibody titers continued 5-6 days and then reduced gradually.The half life period of IgY in the serum was about 5days.It can be concluded that injecting the egg yolk antibody can significantly improve chicken serum antibody titer.