化学
芳基
异恶唑
钯
吡那考
卤化物
铃木反应
催化作用
硼酸
碎片(计算)
药物化学
卤代芳基
有机化学
烷基
计算机科学
操作系统
作者
Juraj Velcicky,Arne Soicke,Roland Steiner,Hans‐Günther Schmalz
摘要
A one-pot protocol for the cyanomethylation of aryl halides through a palladium-catalyzed reaction with isoxazole-4-boronic acid pinacol ester was developed. Mechanistically, the reaction proceeds through (1) Suzuki coupling, (2) base-induced fragmentation, and (3) deformylation as shown by characterization of all postulated intermediates. Under optimized conditions (PdCl2dppf, KF, DMSO/H2O, 130 °C) a broad spectrum of aryl bromides could be converted into arylacetonitriles with up to 88% yield.
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