生物
免疫系统
T细胞
功能(生物学)
免疫学
人口
T细胞受体
先天免疫系统
抗原呈递
细胞生物学
社会学
人口学
作者
Jeff Holderness,Jodi F. Hedges,Andrew G. Ramstead,Mark A. Jutila
出处
期刊:Annual Review of Animal Biosciences
[Annual Reviews]
日期:2013-01-01
卷期号:1 (1): 99-124
被引量:85
标识
DOI:10.1146/annurev-animal-031412-103639
摘要
γδ T cells are a functionally heterogeneous population and contribute to many early immune responses. The majority of their activity is described in humans and mice, but the immune systems of all jawed vertebrates include the γδ T cell lineage. Although some aspects of γδ T cells vary between species, critical roles in early immune responses are often conserved. Common features of γδ T cells include innate receptor expression, antigen presentation, cytotoxicity, and cytokine production. Herein we compare studies describing these conserved γδ T cell functions and other, potentially unique, functions. γδ T cells are well documented for their potential immunotherapeutic properties; however, these proposed therapies are often focused on human diseases and the mouse models thereof. This review consolidates some of these studies with those in other animals to provide a consensus for the current understanding of γδ T cell function across species.
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